PaxVax has raised $22 million in venture capital funding to advance development of its oral cholera vaccine, PXVX0200. The investment gives PaxVax the cash to run a 3,000-patient Phase III trial of the product.
Princeton University will not begin to offer Novartis' meningitis B vaccine to Bexsero to students until next week, but health officials are already considering expanding the campaign to another university. An outbreak at the University of California, Santa Barbara, is the cause of the latest concerns.
A lack of exposure to infections early in life is one of many proposed contributing factors to development of multiple sclerosis. With this in mind, some have questioned whether giving the immune system a light workout could stave off the autoimmune disorder.
For most of the second half of the 20th century, whooping cough was a disease of the past, one of many previously common infections practically eliminated by vaccines. Since the 1980s the bacteria has fought back though, and now FDA researchers have a theory why--vaccines might not be stopping transmission.
In the 25 years since the first World AIDS Day, patient outcomes have improved significantly, but the long-sought-after vaccine remains elusive. As the world commemorated the event this week, two very different projects outlined their plans to combat the virus.
For many people, vaccines trail only clean water on the list of interventions that have had the biggest effect on infectious diseases. Yet with many others fiercely opposed to vaccines, data is needed to support the argument. This week the data arrived, and it makes a strong case for the importance of vaccines.
The GAVI Alliance is adding the inactivated poliovirus vaccine (IPV) to the list of products it makes available for routine immunization in the world's 73 poorest countries. GAVI is encouraging countries to co-finance IPV but not making it mandatory.
While few question the necessity of the Defense Department's investments in protecting military personnel from biological threats, the scale and type of projects is a source of considerable controversy, as shown by the Pentagon's latest push into vaccine manufacturing.
At a time when its Big Pharma peers have sold noncore assets, Sanofi has diversified, with multibillion-dollar acquisitions of Genzyme and Merial adding biotech and animal health assets, respectively. Now, CEO Chris Viehbacher is looking for smaller, bolt-on deals to boost the vaccine business.
When Ranbaxy bought vaccine supplier Biovel in 2010, the then-CEO of the beleaguered Indian generic firm called it an important part of the company's growth strategy. The CEO is long gone, having resigned within months of buying Biovel, and now Ranbaxy is reportedly ready to split up with its vaccine unit too.
Long-running speculation about the future of Novartis' struggling vaccine business now appears to be nearing an end. One way or another, Novartis CEO Joe Jimenez expects the future of the unit to be settled in the coming months.
Since an FDA advisory panel unanimously recommended GlaxoSmithKline's H5N1 vaccine one year ago, links between the vaccine's adjuvant and narcolepsy have strengthened, and the FDA subsequently delayed approval. Now, though, GSK has received its long-sought FDA approval.
The trial found two doses of the adjuvanted cell culture vaccine immunologically protected 85% of participants.
The European Union began looking for a solution to vaccine instability earlier this year, and is now nearing the end of its search. A decision is expected next month, after which the EU will commit $3 million to support development of the vaccine temperature stability project.
China is a big, climatologically-diverse country, with the weather changing significantly between the temperate zones in the north and the subtropical regions further south. This affects when flu seasons occur, and consequently when health authorities should run vaccination campaigns.
When the World Health Organization released its first malaria vaccine technology roadmap in 2006, it put the development of a partly effective vaccine by 2015 at the top of its list of priorities. With GlaxoSmithKline nearing that goal, WHO has revised its plan with new targets for 2030.
While anthrax, smallpox and other "category A" bioterrorism threats dominate the collective public consciousness, a larger pool of lower-priority agents are also a danger. Q fever falls into this second tier, but the U.S. government is still sufficiently concerned to gather researchers to talk vaccine development.
As a meningitis outbreak has slowly spread across Princeton University over the past 8 months, the case for vaccinating students has grown stronger. The only hitch is that the vaccine, Novartis' Bexsero, has yet to win approval in the U.S. Now, though, health authorities are willing to work around this obstacle.
U.K. health authorities have run similar surveys over the past four years, but this is the first time it will capture data from schools.
The reemergence of H7N9 in China during the past month has reinforced the need for a vaccine. Candidates from Chinese and Taiwanese manufacturers have grabbed the headlines recently, but now a U.S. player, Novavax, has joined the race with positive Phase I data.