FierceBiotech FierceBiotech IT FiercePharma FierceMedicalDevices
FierceBiotech Research FierceVaccines FiercePharma Manufacturing FierceDrugDelivery

Free Newsletter

About | View Sample | Privacy
Related Topics >> flu vaccine

Computer scientist engineers tame type of live vax

Free Newsletter

FierceVaccines is a weekly update on the vaccine industry, with a special focus on the innovations revolutionizing the development and production of vaccines. Join thousands of lab research professionals who get FierceVaccines via weekly email. Sign up today!



Tools

A computer scientist at the University of Miami has collaborated with scientists at Stony Brook University to design new and better vaccines that can knock out a virus while laying to rest some of the fears often associated with live vaccines.

Up to now, developers creating live vaccines have relied on a simple approach: Weaken a virus to the point where it is no longer a threat but spurs the immune system to guard against any future attacks of the wild virus. But fears that the weakened live virus can regain virulence have limited their application.

Computer scientist Dimitris Papamichail developed a new method called Synthetic Attenuated Virus Engineering. Working with the Stony Brook team, the group engineered a synthetic genome of the vaccine using computer algorithms to systematically weaken it by changing its genetic code in a multitude of places. The genetic alterations make it virtually impossible for the virus to regain virulence, triggering symptoms, while speeding the process of developing vaccines that can fight the wild-type strains that threat populations.

"Our approach is not only useful for influenza; it is also applicable to a wide range of viruses," says Papamichail. "The probability of all the changes reverting themselves to produce a virulent strain is extremely unlikely."

- here's the release from Science Daily

Related Articles:
Synthetic flu virus opens door to safer vaccines
Vaccine myths fuel some stubborn consumer fears
HHS vows to upgrade U.S. vaccine technology


SHARE
WITH:
Email Twitter Facebook LinkedIn StumbleUpon
Get Your FREE FierceVaccines Email Newsletter:
Be the first to comment
More stories about flu vaccine  

Comments

Post new comment

The content of this field is kept private and will not be shown publicly.

More information about formatting options

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.