FierceBiotechFierceBioResearcherFierceBiotechITFierceVaccinesFiercePharma   FierceHealthcare

Free Newsletter

About | View Sample | Privacy
Related Topics >> MEL11 | Vaccine | melanoma | Sanofi Pasteur

Sanofi Pasteur begins melanoma vaccine trial

  • Email
  • Print
  • Comment
  • Contact Author
  • Reprint

Sanofi pasteur is mounting a mid-stage trial involving 120 patients at 23 centers to test the efficacy of a new melanoma vaccine. The vaccine uses a modified canarypox virus containing the genes for five antigens that induce an immune response to melanoma tumors. These antigens stimulate T-cells within the immune system to zero in on melanoma cells, and are expected to halt or slow cancer progression. The vaccine also contains the genes for three proteins called co-stimulatory molecules, which increase the immune response of T-cells to the antigens. In addition to the vaccine, patients in the trial will be treated with two other agents that augment the immune response: GM-CSF and interferon-alpha-2b.

"The MEL11 study uses an entirely new treatment approach to advanced-stage melanoma," said Teresa Petrella, MD, a researcher at the Odette Cancer Centre at the Sunnybrook Health Sciences Centre in Toronto and the lead investigator of the trial. "The study protocol combines the use of a vaccine with more traditional anti-cancer agents to bolster the effectiveness of the immune system. Melanoma is an increasing concern in the cancer community; its incidence is on the rise and there are very few available treatment options."

- read the release from Sanofi

Related Articles:
Sanofi to plow $6B into vaccines
Sanofi makes $548M deal for Acambis
Sanofi licenses technology for new TB vaccine

More stories about MEL11   Vaccine   melanoma   Sanofi Pasteur  


My husband has Stage iv melanoma of the lung and has just had his second surgery. Would the vaccine help him?

Post new comment

The content of this field is kept private and will not be shown publicly.

More information about formatting options

To combat spam, please enter the code in the image.