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Systems biology key to vaccine breakthroughs?

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In an article published in Nature, Seattle BioMed Director Alan Aderem and head of Novartis' vaccine division Rino Rappuoli note that news tools for vaccine development--including systems biology and structure-based antigen design--could spur research that will wipe out the scourges of malaria, tuberculosis and HIV/AIDS by 2020. Combined, those three diseases kill 5 million people worldwide each year.

"Success will be largely dependent on our ability to use novel approaches such as systems biology to analyze data sets generated during proof-of-concept trials," he explained. "This will lead to new insights such as the identification of correlates of protection or signatures of immunogenicity and the acceleration of large-scale clinical trials."

Systems biology analyzes enormous amounts of biological data to visualize and predict behavior of a biological system, explains Aderem. By predicting how a system will behave, researcher can optimize a vaccine in the earliest stages of development before it reaches expensive late-stage trials. Aderem adds that systems biology can be used to test multiple hypotheses at once, speeding clinical research. "We can accelerate clinical development by performing more efficacy trials and by improving their design using systems biology approaches to test several hypotheses in parallel and having an adaptive design to expand the outcomes that prove most promising," he notes in the article.

- check out the release
- here's the article abstract


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The paper is extremely valuable, because it indicates that the understanding of the System Biology leading to diseases will improve the current diseases treatment and prevention. The infectious diseases cause the oxidative stress and generate an anti-oxidative enzyme indoleamine- 2, 3 -dioxygenase (IDO). IDO produces the small molecules from the tryptophan degradation, which in the condition of disease-associated oxidative stress modify the regulatory sequences of proteins leading to the new system biology, described here:
http://www.jbiomedsci.com/content/pdf/1423-0127-18-7.pdf
The system biology in infection has the new protein-protein interactions and is responsible for the pathological cell death, inflammation, beta-amyloidosis etc. My technology eliminates the misfolded proteins from the modified protein network - the system biology responsible for pathology - and prevents or stops the infectious diseases by the “fit” immune system of the host. Please contact me for collaboration in development of the new anti-infectious vaccines, which restore the host immunity and stop infections.

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