FierceBiotech FierceBiotech IT FiercePharma FierceMedicalDevices
FierceBiotech Research FierceVaccines FiercePharma Manufacturing FierceDrugDelivery

Free Newsletter

About | View Sample | Privacy

Celldex stock hit hard, but cancer vaccine shows promise

Free Newsletter

FierceVaccines is a weekly update on the vaccine industry, with a special focus on the innovations revolutionizing the development and production of vaccines. Join thousands of lab research professionals who get FierceVaccines via weekly email. Sign up today!



Tools

Biotech stocks were rocked last week when Dendreon, which makes the only approved cancer vaccine, reported that sales of Provenge significantly missed their mark. Dendreon lost two-thirds of its market value and dragged the rest of the market down with it.

One of the casualties was Needham, MA-based Celldex. The developer's experimental brain cancer vaccine--called rindopepimut (CDX-110)--recently completed a Phase II trial. The company's stock hit a 52-week low despite a Journal of Clinical Oncology article which showed for the first time that rindopepimut had an effect on brain tumors in patients.

Seeking Alpha explains that it can be very difficult for cancer vaccine developers to prove that their experimental products are clinically active, particularly in early-stage trials. Because rindopepimut is administered to patients who've had their tumor removed and are undergoing radiation and chemotherapy, it's hard for researchers to know whether patient outcomes are the result of the experimental vaccine, or standard care. So Celldex examined a databased of patients whose tumors were EGFRvIII-positive--rindopepimut's target. They found that 16 EGFRvIII-positive patients in the trial who'd received the vaccine became EGFRvIII-negative when they experienced disease recurrence. This "is unequivocal proof that the vaccine is doing something to tumors that express its target," explains Seeking Alpha.

The results will have to be confirmed in a larger trial. The developer plans to start a late-stage trial of rindopepimut this year, with results expected in 2013.

- here's the Seeking Alpha article

Related Articles:
Celldex ($CLDX) touts promise of PhII brain cancer vaccine data
Celldex vax extends life of brain tumor patients in study
Pfizer returns brain cancer vax rights to Celldex


SHARE
WITH:
Email Twitter Facebook LinkedIn StumbleUpon
Get Your FREE FierceVaccines Email Newsletter:

More stories about cancer vaccine   Celldex Therapeutics   CDX-110   rindopepimut