Incredulity turns to praise as malaria vaccine posts positive PhI data
Sanaria has spent the past decade harvesting parasites from the salivary glands of mosquitoes to use in malaria vaccines. The resulting vaccine uses a weakened form of the whole parasite to generate an immune response.
Top 10 pharma companies by employees
Being the largest company by any number of measures--revenues, earnings, those kinds of yardsticks--is a good thing. Being the largest by number of employees is trickier, unless yours is also the largest by those other measures. As we have seen time and again in recent years in the pharma industry, having lots of employees and falling revenues is a formula that leads to layoffs. As a whole, the top 10 companies had fewer employees at the end of 2012 than at the end of 2011. Read the full report >>Major FDA vaccine approvals of 2012
With the books closed on 2012, we can confirm--as expected--that a majority of the major FDA vaccine approvals went to trivalent influenza vaccines. (The FDA is continuing this trend with the first vaccine approval of 2013 going to Flublok.) Manufacturers, after all, need to reformulate them each season. But two new quadrivalent flu vaccines from GlaxoSmithKline and AstraZeneca also joined the ranks, scheduled to hit the market later this year. Read more >>
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Pandemic immune response hints at potential universal flu vax
The search for a universal flu vaccine has focused on the stem of the lollipop-shaped hemagglutinin of the influenza virus. While the composition of the head changes, the stem is fairly constant from strain to strain. New data shows the body takes advantage of this fact too.
Study reconfirms safety of flu vaccine in pregnant women
Research in the journal Obstetrics and Gynecology found that 74,000 pregnant women who received a flu shot, in any trimester, were no more likely to experience pregnancy complications.
Vaccine calms fears of meningitis becoming AIDS-like epidemic
The recent outbreak of bacterial meningitis among gay and bisexual men in New York City raised fears of an AIDS-like epidemic. Things are different this time though. Health authorities have a vaccine to hold back the spread of the disease.
Researchers aim at trial to test whether BCG vaccine cuts risk of allergies
Researchers have linked rising allergy rates to improved hygiene and asked whether the Bacillus Calmette-Guérin vaccine can reverse the trend. Existing data is inconclusive, but an Australian team has seen enough to run a 1,400-person trial into the effect of the vaccine.
Weak Provenge sales send Dendreon shares tumbling
The miss means Dendreon now expects to fail to achieve its modest goal of growing sales year-on-year.
Sanofi advances C. diff vaccine into PhIII
Sanofi Pasteur is entering an important period for its vaccine business. The success of its big bet on a dengue fever vaccine hangs on upcoming late phase data. And its clostridium difficile jab has just entered Phase III, too.
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Researchers in Massachusetts have designed nanoparticles that carry platinum-based drugs with a one-two-three punch against tumors--the radiotherapy-triggered vehicles attack a tumor's blood vessels, kill the cells that lead to cancer recurrence and, finally, release a chemo drug that specifically targets the cancer.
In rats with tendon injuries that were treated with Pluristem Therapeutics' PLacental eXpanded (PLX) stem cell therapy, animals showed tendon healing at two and four weeks following injection, compared to saline-treated rats, according to the Haifa, Israel-based company.
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